Synthesis, characterization and antimicrobial activity of novel Mannich bases

Including this studying synthesis, characterization and antimicrobial evaluation of a new series Mannich base derivatives containing 1,3,4-oxadiazole system The novel compounds synthesis by the reaction 1,3,4-oxadiazole-2-thiol with various secondary amine formaldehyde, structures newly synthesized were confirmed FT.IR 1HNMR spectral data. Invitro anti-microbial activity was evaluated agar nutrient method all against gram +ve organisms such as Staphylococcus aureus, -ve Klebsiella aerogenes fungus Candida albicans. compound 4c shown to be more effective bacteria parasites.